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Type: syrup. Generic Name:Lactulose concentrate oral solution; itsf (5ml) contains 3.4gm of lactulose USP: syrup. Manufacturer/Distributor: Opsonin
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✅ Description:
Indications
Constipation (Chronic Constipation): In all cases of chronic constipation, the initial therapy should include a fiber-rich diet (vegetables, salads, fruits, etc.), enough of liquids, and plenty of physical activity. Lactulose should only be used if these other treatments are ineffective.
Disruptions in the intestinal flora:
In the case of intestinal flora damage (e.g. following long-term antibiotic treatment)
gallbladder disorders
gastrointestinal disorders ( Colitis, Diverticulosis, Megacolon)
Ammonia levels in the blood have risen (hyper ammonia in hepatopathy, portal-systemic encephalopathy)
Pharmacology
Lactulose is a man-made disaccharide. Lactulose is digested in the colon by saccharolytic bacteria, which produces low molecular weight organic acids (mostly lactic acid), which lowers the pH of the colon contents, promotes water retention via an osmotic action, and therefore increases peristaltic activity. Because lactulose is minimally absorbed, the pharmacokinetics of the absorbed substance are unimportant to the primary therapeutic effect.
Dosage & Administration
In constipation ( chronic constipation):
Adults: Initially 3-6 tea spoons daily, In long-term therapy 1½-6 tea-spoons daily
Children up to 14 years: Initially 3 tea spoons daily, In long-term therapy 1-2 tea-spoons daily
Infants and toddlers: Initially 1-2 tea spoons daily, In long-term therapy 1 tea-spoon daily
In damaged intestinal flora:
Adults: 1-2 tea-spoons daily
Children: 1 tea-spoon daily
For reduction of blood ammonia level:
Hyper-ammonium in hepatopathy: a maximum of 18-30 teaspoons daily.
In portal-systemic encephalopathy: hourly doses of 6-9 tea spoons of Lactulose solution may be used to induce rapid laxation. When the laxative effect has been achieved, the dose may then be reduced.
Interaction
There are no known medication interactions with lactulose. In misuse, potassium deprivation can amplify the glycosidic action of cardiac glycosides.
Contraindications
Galactose and/or lactose hypersensitivity; galactose-free diet, gastro-cardial symptom complex, possible intestinal obstruction.
Side Effects
Flatulence, cramping, and stomach pain may occur at the start of therapy; this is quickly alleviated by lowering the dosage. Diarrhea can occur as a result of an overdose. Electrolyte loss occurs with abuse (primarily potassium).
Pregnancy & Lactation
Flatulence, cramping, and stomach pain may occur at the start of therapy; this is quickly alleviated by lowering the dosage. Diarrhea can occur as a result of an overdose. Electrolyte loss occurs with abuse (primarily potassium).
Precautions & Warnings
Lactulose should be provided with caution to individuals who are lactulose intolerant. The dose used in the treatment of (pre) coma hepatic is generally significantly greater, and diabetics should be aware of this.
Storage Conditions
Keep away from light and heat in a dry area. Keep out of children's reach.
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